Cannabis on JPR

Is Marijuana as Safe as We Think?

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    • #9709
      • Total Posts: 11,957

      Figuring out the “dose-response relationship” of a new compound is something a pharmaceutical company does from the start of trials in human subjects, as it prepares a new drug application for the F.D.A. Too little of a powerful drug means that it won’t work. Too much means that it might do more harm than good. The amount of active ingredient in a pill and the metabolic path that the ingredient takes after it enters your body—these are things that drugmakers will have painstakingly mapped out before the product comes on the market, with a tractor-trailer full of supporting documentation.

      With marijuana, apparently, we’re still waiting for this information. It’s hard to study a substance that until very recently has been almost universally illegal. And the few studies we do have were done mostly in the nineteen-eighties and nineties, when cannabis was not nearly as potent as it is now. Because of recent developments in plant breeding and growing techniques, the typical concentration of THC, the psychoactive ingredient in marijuana, has gone from the low single digits to more than twenty per cent—from a swig of near-beer to a tequila shot.

      Are users smoking less, to compensate for the drug’s new potency? Or simply getting more stoned, more quickly? Is high-potency cannabis more of a problem for younger users or for older ones? For some drugs, the dose-response curve is linear: twice the dose creates twice the effect. For other drugs, it’s nonlinear: twice the dose can increase the effect tenfold, or hardly at all. Which is true for cannabis? It also matters, of course, how cannabis is consumed. It can be smoked, vaped, eaten, or applied to the skin. How are absorption patterns affected?

      Last May, not long before Canada legalized the recreational use of marijuana, Beau Kilmer, a drug-policy expert with the RAND Corporation, testified before the Canadian Parliament. He warned that the fastest-growing segment of the legal market in Washington State was extracts for inhalation, and that the mean THC concentration for those products was more than sixty-five per cent. “We know little about the health consequences—risks and benefits—of many of the cannabis products likely to be sold in nonmedical markets,” he said. Nor did we know how higher-potency products would affect THC consumption.

      Jesus: Hey, Dad? God: Yes, Son? Jesus: Western civilization followed me home. Can I keep it? God: Certainly not! And put it down this minute--you don't know where it's been! Tom Robbins in Another Roadside Attraction

    • #10391
      • Total Posts: 5,325

      Besides, who defines ‘safe’ and to what purpose? Is it to eliminate from our environment and our personal lives anything that might have a threat of risk?


      • #10499
        • Total Posts: 11,957

        –to get into a bad relationship with MJ.  But it does happen.

        Jesus: Hey, Dad? God: Yes, Son? Jesus: Western civilization followed me home. Can I keep it? God: Certainly not! And put it down this minute--you don't know where it's been! Tom Robbins in Another Roadside Attraction

        • #10537
          • Total Posts: 8,758

          not legalizing marijuana is kicking in.

          America is not a country, it's just a business. (Brad Pitt, Killing Them Softly)

          "Sometimes when I try to understand a person's motives, I play a little game. I assume the worst. What's the worst reason they could possibly have for saying what they say and doing what they do? Then I ask myself, 'How well does that reason explain what they say and what they do?'" GRRM

          A YouTube comment – we need new conspiracy theories – the old ones have all come true.

    • #19395
      • Total Posts: 6,358

      you’re acting as if THC is new and unstudied

      Nothing could be further from the truth.

      The British found the use of cannabis so extensive in colonial India, that they commissioned a large scale study in the late 1890s (Iverson, 2008). They were concerned that the abuse of cannabis was endangering the health of the native people and driving them insane. The British government asked the government of India to appoint a commission to look into the cultivation of the hemp plant, preparation of drugs from it, trade in those drugs, the social and moral impact of its consumption, and possible prohibition. Over 1,000 standardized interviews were conducted throughout India by eminent British and Indian medical experts. The commission was systematic and thorough. It sampled a large and diverse group of people in a range of situations, from farmers to hospital psychiatrists. After years of detailed work, The Indian Hemp Drugs Commission Report produced six volumes of data and conclusions. Commissioners were particularly concerned with whether or not cannabis caused psychoses. After years of through and well conducted research, The Commission concluded that suppressing the use of herbal cannabis (bhang) would be totally unjustifiable. They concluded that its use is very ancient, has some religious sanction among Hindus, and is harmless in moderation. In fact, more harm was done by alcohol. Furthermore, prohibition would be difficult to enforce, encourage outcries by religious clerics, and possibly lead to the use of more dangerous narcotics. These findings of The Indian Hemp Drugs Commission Report of 1894, conducted over 100 years ago, are surprisingly relevant today.

      Cannabis continues to be available in India of the 20th and 21st centuries. In their review in the mid-fifties, Chopra and Chopra (1957) found little changed since the Indian Hemp Drugs Commission Report of 1894. Construction workers use bhang to feel refreshed at the end of the day and to fight fatigue. Hindus use bhang for religious ceremonies like Holi and ascetics use it to seek divinity. Sadhus are Indian ascetics who have shunned material life and use cannabis to seek spiritual freedom. They live simply in the forest and wear ragged clothing. By emphasizing physical austerity through celibacy and fasting, cannabis helps sadhus transcend ordinary reality and achieve transcendence. Today, bhang is so common in some parts of India that it can be found in government licensed street stands. In sum, the herbal plant, cannabis, has a long and continuous history in India. It has lived for thousands of years in stories of gods and warriors and it continues to live today in religious ceremonies and street stands.

      Over 100 Scientific Studies Agree: Cannabis Annihilates Cancer

      The healing properties of cannabis are nothing new. In ancient India, cannabis was used to treat ailments such as insomnia and pain. The Greeks used it to cure ailments such as nosebleeds and tapeworms. In Medieval Islam, history shows cannabis used as a diuretic, antiemetic, and antiepileptic (1).

      Even in the West, cannabis was the primary pain reliever prescribed by doctors until Aspirin took its place in 1897. Up until the “war on drugs” began around 1937, there were at least 2000 different cannabis-based medicines on the market (2).

      Yup take more cure cancer faster.

      More powerful smoke less.

      Safe as houses.

      “Never argue with a fool, onlookers may not be able to tell the difference.”
      ~Samuel Clemens

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